TA107

Breast cancer (early) - trastuzumab (TA107)

  • Technology appraisals TA107
  • Issued: August 2006
    • Trastuzumab for the adjuvant treatment of early-stage HER2-positive breast cancer

      NICE clinical guideline 80 (Breat cancer: early and locally advanced, published in February 2009) updates the recommendations contained in this appraisal.

      Trastuzumab treatment should be offered as an option for women with early-stage HER2-positive breast cancer after they have had surgery and chemotherapy (and sometimes radiotherapy).

      Trastuzumab should be given once every 3 weeks for 12 months, or until the breast cancer comes back, whichever is sooner.

      Trastuzumab treatment has been associated with heart problems. Before trastuzumab is prescribed a woman should have tests to check how well her heart is working. The tests should be repeated every 3 months during treatment. If a woman develops heart problems while taking trastuzumab her treatment will be stopped.

      Trastuzumab should not be offered to women with certain heart problems or with high blood pressure that is not well controlled with drugs or other treatment.


      • Correction

        It has been brought to our attention that this guidance contained an error in section 1.3, where it stated that:

        ‘Cardiac functional assessments should be repeated every 3 months during trastuzumab treatment. If the LVEF drops by 10% from baseline and to below 50% then trastuzumab treatment should be suspended…?

        This has now been amended so that it follows more closely the SPC for trastuzumab, as follows:

        ‘Cardiac functional assessments should be repeated every 3 months during trastuzumab treatment. If the LVEF drops by 10 percentage (ejection) points or more from baseline and to below 50% then trastuzumab treatment should be suspended…?

        Electronic versions of the guidance have been amended below. Printed copies of the amended quick reference guide will be available shortly from the NHS Response Line; telephone 0870 1555 455 and quote reference number N1111.

        Update to guidance

        CG80 Early and locally advanced breast cancer updates the recommendations contained in this appraisal.   NICE and the Department of Health are currently reviewing the future position on updating technology appraisals within clinical guidelines, with particular reference to implications for the funding direction on technology appraisals. In the meantime, the technology appraisal guidance remains available and should continue to be followed. The statutory funding direction remains in place for the recommendations contained in the technology appraisal guidance.

      • Other information

        NICE Pathways

        This guidance has been incorporated into the following NICE Pathways, along with other related guidance and products.

        Visit the NICE Pathway: early and locally advanced breast cancer

        How this guidance was produced

        Background information

      This page was last updated: 17 February 2014

    • Guidance formats

      Query

      Information for the public Breast cancer (early) - trastuzumab

      Information for the public

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Patient

The summary of the key recommendations in the guidance written for patients, carers and those with little medical knowledge and may be used in local patient information leaflets.

Quick Reference Guide

The quick reference guide presents recommendations for health professionals

NICE Guidance

The published NICE clinical guidance, contains the recommendations for health professionals and NHS bodies.

Full Guidance

The published full clinical guidance for specialists with background, evidence, recommendations and methods used.

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Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.