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Hyperparathyroidism - cinacalcet

Cinacalcet for the treatment of secondary hyperparathyroidism in patients with end-stage renal disease on maintenance dialysis therapy

Guidance type:  Technology appraisal
Date issued:  January 2007

We will consult on our review plans for this guidance in December 2009.

Reference:  TA117

Summary

Cinacalcet is not generally recommended for treating people on dialysis who have hyperparathyroidism because of their kidney disease. However, it is recommended for people on dialysis who:

  • have very high levels of parathyroid hormone in their blood that can't be lowered by other treatments, and
  • cannot have an operation to remove the parathyroid glands (a parathyroidectomy), because of the risks involved.

People who do receive cinacalcet should have regular checks. Treatment should be stopped if the parathyroid hormone levels in their blood do not fall substantially within 4 months.

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