NICE research uncertainties are unanswered research questions that emerge during guidance development and published as research recommendations by the Science Policy and Research (SP&R) programme.

The recommendations are developed using the NICE research recommendations interim process and methods guide, which supports NICE guidance producers in making research recommendations (for example, from identifying uncertainties to prioritising research recommendations).

As NICE does not have an annual budget for primary research, it has close engagement and arrangements with the National Institute for Health Research (NIHR) to identify and address research priorities. The engagement is carried out through regular meetings on an annual cyclical basis.


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