The NICE clinical guideline on long-acting reversible contraception (LARC) offers the best-practice advice for all women of reproductive age who may wish to regulate their fertility by using LARC methods. It covers specific issues for the use of these methods during the menarche and before the menopause, and by particular groups, including women who have HIV, learning disabilities or physical disabilities, or are younger than 16 years.
May 2013: Update of the recommendations on progestogen-only subdermal implants
The progestogen-only subdermal implant, Implanon, recommended in this guideline is no longer available.
Implanon was replaced by Nexplanon. Nexplanon contains the same amount of the same drug as Implanon, but the summaries of product characteristics for the two devices are not identical.
In the light of the change in the implant available, NICE will review the evidence and update the section of the guideline that makes recommendations on progestogen-only subdermal implants.
Healthcare professionals considering offering Nexplanon should consult the summary of product characteristics.
June 2006: The recommendation on treating irregular bleeding after insertion of a contraceptive implant has been changed (this is recommendation 220.127.116.11 in the NICE guideline). Although the evidence does show that mifepristone is effective at controlling irregular bleeding associated with implants, it is not licensed for this indication. The revised recommendation reads: 'Irregular bleeding associated with implant use can be treated with mefenamic acid or ethinylestradiol.'