Next review date: March 2016

This guideline updates and replaces NICE guideline CG82 (published in March 2009). It offers evidence-based advice on the care of adults with psychosis and schizophrenia.

March 2014:

A correction has been made to the wording of recommendation to be clear that it is the hydrocarbons in cigarette smoke that cause interactions with other drugs, rather than nicotine.

The corrected recommendation reads:

Offer people with psychosis or schizophrenia who smoke help to stop smoking, even if previous attempts have been unsuccessful. Be aware of the potential significant impact of reducing cigarette smoking on the metabolism of other drugs, particularly clozapine and olanzapine.


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