Prophylaxis against infective endocarditis: Antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures

NICE guidelines [CG64] Published date:

Review decision: 

Following consultation with stakeholders this guideline has now been placed on the static list. 

Next review date: TBC

The advice in this NICE guideline covers:

Patients who are at risk of infective endocarditis, specifically:

  • adults and children with certain problems affecting the structure of the heart (such as a replacement heart valve or hypertrophic cardiomyopathy)
  • adults and children who have previously had infective endocarditis (whether or not they have an underlying cardiac problem)
  • people having any of these procedures:

- any dental procedure

- any obstetric or gynaecological procedure, or childbirth

- any procedure on the bladder or urine system

- any procedure on the gullet, stomach or intestines

- any procedure on the airways, including ear, nose and throat procedures and bronchoscopy (a test used to diagnose some lung problems).

It does not specifically look at:

  • people at risk of infective endocarditis who do not have heart problems (such as intravenous drug users)
  • people having procedures that aren't in the list above

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