High dose rate brachytherapy in combination with external-beam radiotherapy for localised prostate cancer

NICE interventional procedure guidance [IPG174] Published date:

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The National Institute for Health and Clinical Excellence (NICE) has issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on high dose rate brachytherapy in combination with external-beam radiotherapy for localised prostate cancer in May 2006.

Further recommendations have been made as part of the clinical guideline on prostate cancer published in February 2008, as follows:

Brachytherapy is not recommended for men with high-risk localised prostate cancer.

Clinical and cost-effectiveness evidence was reviewed in the development of this guideline which has led to this more specific recommendation. More information is available from www.nice.org.uk/cg58. The IP guidance on high dose rate brachytherapy in combination with external-beam radiotherapy for localised prostate cancer remains current, and should be read in conjunction with the clinical guideline.

  • Description

    Prostate cancer is one of the most common cancers in men. It tends to affect older men, with the risk rising with age. It is not a single disease entity but may be indicated form an incidental biopsy finding to presentation with metastatic prostate cancer, which may or may not cause any symptoms or shorten life. Symptoms when they occur include urinary outflow obstruction and features of metastases, such as bone pain. Prognosis with prostate cancer is variable and depends on the grade of the tumour and stage of the diagnosed cancer. Treatment options depend on the stage of the cancer. 

     Brachytherapy is a form of radiotherapy in which delivery of radiation is targeted directly to the prostate gland through the implantation of small radioactive pellets. Needles are inserted through the skin of the perineum, these needles deliver the seeds which are left in place. In high dose rate brachytherapy thin plastic catheters are inserted through a template, through the perineal skin, and into the prostate gland. They enter the skin below the scrotum and above the rectum. A radioactive seeds are then inserted into each catheter. The catheters are then pulled out, leaving no radioactive material in the prostate gland. Brachytherapy may be used in combination with external beam radiation (EBRT) in high dose therapy.

  • OPCS4.6 Code(s)

    M70.6 Radioactive seed implantation into prostate

    Note: Use an additional code to specify radiotherapy delivery (X65)

    X65.3 Delivery of a fraction of interstitial radiotherapy

    Note: Use a subsidiary code to identify introduction of radioactive material (Y35, Y36)

    Y36.3 Radioactive seed implantation NOC

    Y89.1 High dose rate brachytherapy treatment


     Note:An external beam radiotherapy code X65.4 Delivery of a fraction of external beam radiotherapy NEC plus a code from category Y91. - External beam radiotherapy is assigned on the appropriate episode when this occurs.



    In addition the ICD-10 code C61.X Malignant neoplasm of prostate or C79.8 Secondary malignant neoplasm of other specified sites is assigned



    The NHS Classifications Service of the Health and Social Care Information Centre is the central definitive source for clinical coding guidance and determines the coding standards associated with the classifications (OPCS-4 and ICD-10) to be used across the NHS.  The NHS Classifications Service and NICE work collaboratively to ensure the most appropriate classification codes are provided.  http://systems.hscic.gov.uk/data/clinicalcoding

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