Hypercholesterolaemia - ezetimibe (TA132)
Fast, easy summary view of NICE guidance on 'familial hypercholesterolaemia'
Ezetimibe for the treatment of primary (heterozygous-familial and non-familial) hypercholesterolaemia
Ezetimibe is recommended as a possible treatment for adults with primary (heterozygous-familial and non-familial) hypercholesterolaemia in the following circumstances.
- Ezetimibe can be taken on its own by a person who would normally be given a statin to treat their condition but can't because the person has a condition or takes another medicine that interferes with how the statin works, or because the statin is likely to cause side effects.
- Ezetimibe can be taken at the same time as a person's usual statin rather than changing to a new statin when cholesterol levels are not low enough despite increasing the dose of the statin, or if a person is unable to try higher doses of the statin because it is likely to cause side effects.
When a person has side effects from using a statin, this is described as 'intolerance'. Side effects include muscle pain, severe stomach problems or when tests indicate that the liver is not functioning normally.
A decision on whether a person's cholesterol level is low enough should be based on an individual risk assessment.
If it is decided that a person should take their usual statin and ezetimibe together, then the least expensive form of ezetimibe should be prescribed.
This guidance has been incorporated into the following NICE Pathways, along with other related guidance and products.
Visit the NICE Pathway: familial hypercholesterolaemia
- Hypercholesterolaemia - ezetimibe: review decision - June 2012
- Hypercholesterolaemia - ezetimibe: review proposal - February 2012
- TA132 Hypercholesterolaemia - ezetimibe: review update - August 2011
- NICE issues guidance on ezetimibe for primary hypercholesterolaemia
- Hypercholesterolaemia - ezetimibe: review decision - November 2010
This page was last updated: 12 August 2013
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