Appendix B: Sources of evidence considered by the Committee

A. The Evidence Review Group (ERG) report for this appraisal was prepared by the Department of Public Health and Epidemiology University of Birmingham:

Bryan S et al. Infliximab for the treatment of acute exacerbations of ulcerative colitis, June 2008.

B. The following organisations accepted the invitation to participate in this appraisal. They were invited to comment on the draft scope, the ERG report and the appraisal consultation document (ACD). Organisations listed in I were also invited to make written submissions. Organisations listed in II gave their expert views on infliximab for the treatment of acute exacerbations of ulcerative colitis by providing a written statement to the Committee. Organisations listed in I and II have the opportunity to appeal against the final appraisal determination.

I) Manufacturer/sponsor:

Schering Plough

II) Professional/specialist and patient/carer groups:

National Association for Colitis and Crohn's Disease (NACC)
Association of Coloproctology of Great Britain and Ireland
British Society of Gastroenterology
Royal College of Nursing
Royal College of Pathologists
Royal College of Physicians

III) Other consultees

Department of Health
Medway PCT
Welsh Assembly Government

IV) Commentator organisations (did not provide written evidence and without the right of appeal)

British National Formulary
Department of Health, Social Services and Public Safety for Northern Ireland
NHS Quality Improvement Scotland
Novartis Pharmaceuticals UK Ltd
West Midlands Health Technology Assessment Collaboration
National Collaborating Centre for Nursing and Supportive Care

C. The following individuals were selected from clinical specialist and patient advocate nominations from the non-manufacturer/sponsor consultees and commentators. They gave their expert personal view on infliximab for the treatment of acute exacerbations of ulcerative colitis by attending the initial Committee discussion and providing written evidence to the Committee. They were also invited to comment on the ACD.

Professor Jon Rhodes, nominated by Royal College of Physicians – clinical specialist.
Professor David Rampton, nominated by Royal College of Physicians – clinical specialist.
Richard Driscoll (Director), nominated by The National Association for Colitis and Crohn's Disease – patient expert.
Mr Stuart Berliner (Director), nominated by The National Association for Colitis and Crohn's Disease – patient expert.