Ustekinumab for the treatment of adults with moderate to severe psoriasis

NICE technology appraisals [TA180] Published date:

Ustekinumab is recommended as a possible treatment for people with plaque psoriasis if:

  • standard assessments show that their psoriasis is severe and is affecting their quality of life and
  • their psoriasis has not improved with other treatments including ciclosporin, methotrexate and PUVA (psoralen and long-wave ultraviolet radiation), or they have had side effects with these treatments in the past or there is a medical reason why they should not be given them.

The manufacturer of ustekinumab has agreed to a ‘patient access scheme’ which means that they provide the higher dose needed for people who weigh more than 100 kg at the same total cost as the lower dose for people who weigh 100 kg or less.

Ustekinumab treatment should be stopped if standard assessments show that a person’s psoriasis has not clearly improved after 16 weeks.

When assessing how a person’s psoriasis affects their quality of life, healthcare professionals should take into account any disabilities or difficulties in communicating which might mean that the standard assessments do not provide accurate information.

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