Hepatitis C - peginterferon alfa and ribavirin (TA200)
This guidance should be read in conjunction with the following NICE guidance:
- NICE technology appraisal guidance 75 (TA75) 'Interferon alfa (pegylated and non-pegylated) and ribavirin for the treatment of chronic hepatitis C' (which covers moderate to severe hepatitis C)
- NICE technology appraisal guidance 106 (TA106) 'Peginterferon alfa and ribavirin for the treatment of mild chronic hepatitis C'.
This appraisal addresses extensions to the marketing authorisations for peginterferon alfa-2a and peginterferon alfa-2b. This guidance updates and replaces:
- section 1.2, bullet 3 only, of TA75
- section 1.4 of TA75 for adults who are eligible for shortened courses of combination therapy (as described in section 1.2 of the current guidance)
- section 1.7, bullet 1 only, of TA75
- sections 1.4 and 1.5 of TA106.
All other recommendations in TA75 and TA106 still stand.
NICE recommends peginterferon alfa (2a or 2b) plus ribavirin as a possible treatment for people with chronic hepatitis C:
- who have been treated previously with peginterferon alfa (2a or 2b) plus ribavirin, or with peginterferon alfa monotherapy, but their hepatitis C didn't improve, or improved but then got worse again or
- who also have an HIV infection.
NICE also recommends short courses of treatment with peginterferon alfa (2a or 2b) plus ribavirin for people whose hepatitis C has greatly improved within 4 weeks of starting treatment and who are suitable for short treatment courses . Whether a person is suitable for a short treatment course will depend on a number of factors.
In June 2011, sections 3.11, 3.12 and 4.1.5 of the guidance were amended to correct an error in the stated dose of ribavirin. The doses of ribavirin should be in mg (milligrams), and not micrograms.
This page was last updated: 10 October 2013
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