This guidance updates and replaces sections 1.2 (bullet 3 only), 1.4 (as described in section 1.2 of the current guidance) and 1.7 (bullet 1 only) of NICE technology appraisal 75 (published in January 2004).

This guidance also updates and replaces sections 1.4 and 1.5 of NICE technology appraisal 106 (published in August 2006).

All other recommendations in TA75 and TA106 still stand.

NICE recommends peginterferon alfa (2a or 2b) plus ribavirin as a possible treatment for people with chronic hepatitis C:

  • who have been treated previously with peginterferon alfa (2a or 2b) plus ribavirin, or with peginterferon alfa monotherapy, but their hepatitis C didn't improve, or improved but then got worse again or
  • who also have an HIV infection.

NICE also recommends short courses of treatment with peginterferon alfa (2a or 2b) plus ribavirin for people whose hepatitis C has greatly improved within 4 weeks of starting treatment and who are suitable for short treatment courses . Whether a person is suitable for a short treatment course will depend on a number of factors.

  • In June 2011, sections 3.11, 3.12 and 4.1.5 of the guidance were amended to correct an error in the stated dose of ribavirin. The doses of ribavirin should be in mg (milligrams), and not micrograms.

    • NICE has accredited the process used by the Centre for Health Technology Evaluation at NICE to produce technology appraisals guidance. Accreditation is valid for 5 years from September 2009 and applies to guidance produced since June 2008 using the processes described in NICE's 'The guide to the methods of technology appraisal' (2008). More information on accreditation can be viewed at