This guidance updates and replaces NICE technology appraisal 122 (published in June 2007).

NICE recommends alteplase as a possible treatment for people who have had an acute ischaemic stroke.

Who can have alteplase?

You should be able to have alteplase if you have had a brain scan that shows that you do not have bleeding within your brain. Your treatment should start as soon as possible and not more than 4½ hours after your stroke symptoms began.

Why has NICE said this?

NICE looks at how well treatments work, and also at how well they work in relation to how much they cost the NHS. NICE recommended alteplase because it works well and is good value for money.

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