The use of autologous chondrocyte implantation for the treatment of cartilage defects in the knee joints

NICE technology appraisals [TA89] Published date:

ACI is not recommended for treating knee problems caused by damaged articular cartilage, unless it is used in studies that are designed to produce good-quality information about the results of the procedure. These results should include measuring any improvement in patients’ quality of life, and the benefits and risks of ACI over a long period of time.

If ACI is offered as part of a clinical study, the doctor should explain that there are uncertainties about the long-term benefits of this procedure and the possible risks, such as locking of the knee, infections and not being able to fully straighten the leg.

  • This guidance updates and replaces NICE technology appraisal 16 (published in December 2000)

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