This guidance has been partially updated by NICE guideline CG165.

Recommendation 1.1 has been incorporated into NICE guideline CG165 as recommendation 1.5.8:

Peginterferon alfa-2a is recommended as an option for the initial treatment of adults with chronic hepatitis B (HBeAg-positive or HBeAg-negative), within its licensed indications.

Recommendations 1.2, 1.3 and 1.4 have been replaced by recommendations 1.5.13, 1.5.14 and 1.5.15 in NICE guideline CG165.

Adefovir dipivoxil is no longer recommended for the treatment of chronic hepatitis B.