1 Guidance
1.1 Pembrolizumab is recommended as an option for treating advanced (unresectable or metastatic) melanoma in adults only:
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after the disease has progressed with ipilimumab and, for BRAF V600 mutation‑positive disease, a BRAF or MEK inhibitor and
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when the company provides pembrolizumab in line with the commercial access agreement with NHS England.