Navigation

ESUOM1 Significant haemorrhage following trauma: tranexamic acid

Key points from the evidence

Tranexamic acid is an antifibrinolytic agent used to prevent, stop or reduce unwanted bleeding. It is licensed for use as a tablet or injection to prevent or reduce bleeding for a range of other indications such as menorrhagia.

Following trauma, tranexamic acid can be administered as an intravenous bolus injection followed by an infusion over 8 hours. However, it does not currently have a UK marketing authorisation for the prevention or treatment of significant haemorrhage following trauma. Use of tranexamic acid in trauma patients will be off-label.

Evidence from a large, high-quality international randomised controlled trial (RCT) shows that a short course of tranexamic acid given within 8 hours of injury to adult trauma patients with, or at risk of, significant bleeding, improved all cause mortality.

A further, exploratory analysis found that death due to bleeding was reduced if tranexamic acid was administered up to 3 hours from injury. However, death due to bleeding seemed to increase with administration later than 3 hours after injury.

A health economic analysis has found that tranexamic acid for the prevention and treatment of significant haemorrhage in trauma patients has an incremental cost of $64 international dollars (£43) per life saved.

Read the full summary

Read the information for the public

RCPCH statement on the use of tranexamic acid in children for major trauma

This page was last updated: 12 December 2013

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.

Selected, reliable information for health and social care in one place

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.