Block scoping reports

Linked below are the Technology Appraisal block scoping reports which have been submitted to the Department of Health. These reports summarise the results of consultation and scoping workshop discussions. This information helps ministers to decide whether or not a technology should be formally referred to NICE for appraisal and whether it should be referred as an MTA or an STA. If ministers decide to refer a technology, the technology is formally referred to NICE for appraisal along with the final remit.

Please note that any 'commercial in confidence' information has been removed.

If you have any questions about this page please email Michelle Adhemar.

Batch 21 block scoping report

Download the batch 21 block scoping report

• Aflibercept in combination with irinotecan and fluorouracil-based therapy for the treatment of metastatic colorectal cancer which has progressed following prior oxaliplatin-based chemotherapy
• Aflibercept solution for injection for the treatment of wet age-related macular degeneration
• Axitinib for the treatment of advanced renal cell carcinoma after failure of prior systemic treatment
• Pegloticase for the treatment of hyperuricaemia in people with symptomatic gout
• Pemetrexed for maintenance treatment following induction therapy with pemetrexed and cisplatin for non squamous non-small-cell lung cancer
• Ruxolitinib for the treatment of myelofibrosis
• Dapagliflozin for the treatment of type 2 diabetes

Batch 20 block scoping report

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• Abiraterone acetate for the treatment of chemotherapy naïve metastatic castrate-resistant prostate cancer
• Apixaban for the prevention of stroke and systemic embolism in people with atrial fibrillation
• Bosutinib for the first-line treatment of Philadelphia chromosome positive chronic myeloid leukaemia in the chronic phase
• Crizotinib for the treatment of non-small-cell lung cancer associated with an anaplastic lymphoma kinase fusion gene
• Denosumab for prolonging bone metastasis-free survival in castrate-resistant prostate cancer
• Lapatinib in combination with paclitaxel for the first-line treatment of HER2 positive metastatic breast cancer
• Rifaximin for the maintenance treatment of hepatic encephalopathy
• Romidepsin for the treatment of relapsed or refractory peripheral T-cell lymphoma
• Vorinostat in combination with bortezomib for the treatment of multiple myeloma in people who have received at least one prior therapy

Batch 19 block scoping report

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• Vemurafenib for the treatment of unresectable locally advanced or metastatic BRAFV600 mutation-positive malignant melanoma
• Ivabradine for the treatment of chronic heart failure
• Bevacizumab for the treatment of platinum-sensitive or partially platinum-sensitive recurrent advanced ovarian cancer (including fallopian tube and primary peritoneal cancer)
• Bevacizumab in combination with chemotherapy for the second line treatment on human epidermal growth factor 2 (HER 2) negative metastatic breast cancer
• Ridaforolimus for the maintenance treatment of metastatic soft tissue or bone sarcoma.

Batch 18 block scoping report

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• Adalimumab for children and young people aged 6-17 with moderate to severe Crohn's disease
• Botulinum toxin type A of the for the prophylaxis of headaches in adults with chronic migrane
• Lenalidomide for the maintenance treatment of multiple myeloma after autologous stem cell transplantation
• Lenalidomide for the treatment of newly diagnosed multiple myeloma
• Lenalidomide for the treatment of myelodysplastic syndromes associated with deletion 5q cytogenetic abnormality.
• Erlotinib for the first line treatment of EGFR-TK mutation positive non-small-cell lung cancer

Batch 17 block scoping report

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• Atrial fibrillation- vernakalant (recent onset- first line)
• Gout- canakinumab
• Hepatitis C (genotype 1) - boceprevir
• Hepatitis C (genotype 1) - telaprevir
• Prostate cancer (meta castration resistant)-abiraterone
• Venous Thromboembolism (prevention) hospitalisation - rivaroxaban

Batch 16 block scoping report

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• Pegaptanib sodium for the treatment of diabetic macular oedema
• Plerixafor for heamatopoietic stem cell mobilisation prior to autologous stem cell transplantation in the treatment of lymphoma
• Plerixafor for heamatopoietic stem cell mobilisation prior to autologous stem cell transplantation in the treatment of multiple myeloma
• Prolonged-release fampridine for the improvement of walking ability in multiple sclerosis
• Duloxetine for the treatment of chronic somatic pain
• Percutaneous vertebroplasty and percutaneous kyphoplasty for the treatment of osteoporotic vertebral fractures
• Adalimumab for the treatment of juvenile idiopathic arthritis
  (Rescoping to cover an application for a licence extension, not part of Batch 16)

Batch 15 block scoping report

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• Bevacizumab in combination with paclitaxel and carboplatin for the first-line treatment of advanced and/or metastatic ovarian cancer
• Asenapine for the treatment of moderate to severe manic episodes associated with bipolar 1 disorder
• Rivaroxaban for the treatment and secondary prevention of venous thromboembolism
• S1 for the treatment of advanced gastric cancer
• Bendamustine in combination with rituximab for the first-line treatment of low-grade non-Hodgkin's lymphoma
• Tapentadol for the treatment of severe chronic pain

Batch 14 block scoping report

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• Diabetic macular oedema - flucinolone acetonide intravitreal insert
• Lymphoma (relapsed or refractory follicular non-Hodgkin's)- bortezomib
• Non Hodgkin's lymphoma (relapsed refractory, 3^rd/4^th line)- pixantrone dimaleate
• Osteoarthritis (2^nd line) - naproxcinod
• Stoke prevention in atrial fibrillation - rivaroxaban
• Systemic lupus erythematosus (active seropositive) - belimumab

Batch 13 block scoping report

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• Cabazitaxel for the second line treatment of hormone refractory, metastatic prostate cancer
• Retigabine for the adjunctive treatment of partial onset seizures in epilepsy
• Eribulin for the treatment of locally advanced or metastatic breast cancer
• Adalimumab for the treatment of acute exacerbations of ulcerative colitis
• Adalimumab for the treatment of sub-acute exacerbations of ulcerative colitis
• Pralatrexate for the treatment of relapsed or refractory peripheral T-cell lymphoma

Batch 12 block scoping report

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• Diabetic macular oedema - ranibizumab
• Leukaemia (acute myeloid) - decitabine (1^stline)
• Leukaemia (chronic myeloid) - dasatinib (1^stline)
• Lung cancer (non-small cell) - BIBW 2992
• Rheumatoid Arthritis - abatacept (2^nd line)
• Chronic iron overload - deferasirox and deferiprone

Batch 11 block scoping report

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• Acute hypertension - clevidipine
• Biopolar 1 disorder - risperidone
• Chronic Iron overload - defasirox and deferiprone
• COPD- Roflumilast
• Cystic fibrosis- colistimethate sodium powder
• Depression - agomelatine
• Depression - quetiapine
• Generalised anxiety disorder - quetiapine
• Idiopathic pulmonary fibrosis - pirfenidone
• Macular oedema (retinal vein occlusion) - dexamethasone
• Macular oedema with central retinal vein occlusion - ranibizumab
• Myocardial infarction - bivalirudin
• Obesity- lorcaserin
• Venom anaphylaxis - immunotherapy pharmalgen

Batch 10 block scoping report

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• Diabetes (type 2) - exenatide (long acting 2nd line in combination)
• Metastatic breast cancer - fulvestrant
• Non-hodgkin's lymphoma - bendamustine
• Multiple Myeloma - bendamustine
• Osteoarthritis- diacerein
• Rheumatoid Arthritis - rituximab
• hornic lymphocytic leukaemia - bendamustine
• Urothelial tract carcinoma - vinflunine

Batch 9 block scoping report

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• Buccal insulin for the management of type 1 diabetes
• Apixaban for the prevention of venous thromboembolism in people undergoing elective knee and hip replacement surgery.
• Apixaban for the prevention of venous thromboembolism in acute medical illness
• Aripiprazole for the treatment and prevention of acute manic and mixed episodes in bipolar disorder in children and adolescents