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Individual research recommendation details

Recommendation details

Recommendation ID: CG57/4
Question: Adverse effects of topical corticosteroids:- What are the long-term effects (when used for between 1 and 3 years) of typical use of topical corticosteroids in children with atopic eczema?
Page: 33
Any explanatory
notes (if applicable):
Why this is important:- Around 70‚??80% of parents and carers of children with atopic eczema are concerned about the side effects of topical corticosteroids and this often prevents adherence to therapy (at least 25% of parents and carers report nonusage because of anxiety). Despite the fact that topical corticosteroids have been in clinical use since 1962, there are limited data on their long-term effects (greater than a few weeks) on skin thickness, hypothalamic‚??pituitary‚??adrenal (HPA) axis suppression and other side effects. Clinical consensus suggests that long-term usage, within clinically recommended dosages, appears to be safe; research confirming this would greatly improve adherence to therapy and clinical outcomes, and reduce parental anxiety. The research could include comparisons between children who use topical corticosteroids for shorter and longer periods, and with those who use other topical preparations such as emollients and topical calcineurin inhibitors.

Source guidance details

Comes from guidance: Atopic eczema in children
Number: CG57
Date issued: Dec 2007

Research needed into:

Effectiveness of treatment: Yes
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: Headings integrated
Date this record updated: 30-04-2010

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.