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Individual research recommendation details

Recommendation details

Recommendation ID: CG86/3
Question: Dietary assessment of gluten content of diet before serological testing: what is the minimum gluten dietary content necessary for the optimal accuracy of serological tests and intestinal biopsy for the diagnosis of coeliac disease?
Page: 59
Any explanatory
notes (if applicable):
There is no robust evidence on how much gluten people should include in their diet when undergoing testing for coeliac disease. Different definitions are used, based on a single study and expert opinion, and this can lead to confusion among patients and clinicians. Although it is evident that a gluten-containing diet for a sustained period is necessary to ensure that serological test results are as accurate as possible and that intestinal biopsy results are as clear as possible, the amount of gluten and the period of intake needed are unknown. Research is needed on how serological tests and intestinal biopsy accuracies are associated with gluten intake in order to define the minimum level of gluten and period of intake for adults and children with suspected coeliac disease.

Source guidance details

Comes from guidance: Coeliac disease
Number: CG86
Date issued: May 2009

Research needed into:

Effectiveness of treatment: No
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: 0
Date this record updated: 30-04-2010

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This page was last updated: 20 March 2014

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.