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Individual research recommendation details

Recommendation details

Recommendation ID: CG86/6
Question: Should repeat serological testing for coeliac disease be performed, and if so, how often?
Page: 60
Any explanatory
notes (if applicable):
Currently, serological tests (tTGA and EMA) for coeliac disease are both relatively sensitive and specific, with low rates of false-negative results. It is not clear whether coeliac disease develops over time (that is, an individual can be tested for coeliac disease at one point in time and be true-negative and then tested at a later point in time, and be true-positive). There is a lack of evidence on the need for repeat testing. Studies are needed to determine whether serological tests should be repeated if the initial results are negative and there is no high clinical suspicion of coeliac disease, and if so, when and how often they should be repeated.

Source guidance details

Comes from guidance: Coeliac disease
Number: CG86
Date issued: May 2009

Research needed into:

Effectiveness of treatment: No
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: 0
Date this record updated: 30-04-2010

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This page was last updated: 20 March 2014

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.