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Individual research recommendation details

Recommendation details

Recommendation ID: CG142/3
Question: Pharmacological treatments for depression in adults with autism:- What is the clinical and cost effectiveness of selective serotonin reuptake inhibitors (SSRIs) for the treatment of moderate and severe depression in adults with autism?
Page: 42
Any explanatory
notes (if applicable):
Why this is important:- Depression commonly coexists with autism and is associated with poorer health outcomes and quality of life. This may occur because of the direct impact of the depression but also because of a negative interaction with the core symptoms of autism. There is poor recognition and consequently suboptimal treatment for depression in adults with autism. However, it is probable that when depression is recognised the most commonly used treatment is antidepressant medication as it is an effective intervention for moderate to severe depression. Little is known about the extent of the use of antidepressant medication, adherence to prescribed medication and its effectiveness in adults with autism. Moreover, concerns have also been raised about the increased sensitivity of people with autism to the side effects of SSRIs and other antidepressant drugs. The suggested programme of research would need to: (a) describe the current use of SSRIs in adults with depression and autism; (b) review the potential impact of increased sensitivity of adults with autism to the side effects of medication; and (c) formally evaluate the outcomes (including symptoms, satisfaction and quality of life) of SSRIs in a series of randomised controlled trials.

Source guidance details

Comes from guidance: Autism in adults
Number: CG142
Date issued: Jun 2012

Research needed into:

Effectiveness of treatment: No
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: 0
Date this record updated: 10-07-2012

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.