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Individual research recommendation details

Recommendation details

Recommendation ID: CG149/3
Question: Intrapartum antibiotic prophylaxis in preterm labour:- What is the clinical and cost effectiveness of intrapartum antibiotic prophylaxis using benzylpenicillin in women with preterm labour?
Page: 30
Any explanatory
notes (if applicable):
Why this is important:- In the absence of unequivocal evidence of clinical and cost effectiveness of intrapartum antibiotic prophylaxis to prevent early-onset neonatal infection in the babies of all women with preterm labour, the recommendation to consider intrapartum antibiotic prophylaxis for women with preterm labour and either prelabour rupture of membranes or confirmed or suspected rupture of membranes of 18 hours' duration or longer was based on the Guideline Development Group's consensus view and knowledge of current practice. Further research is needed to evaluate the clinical and cost effectiveness of intrapartum antibiotic prophylaxis using benzylpenicillin compared with placebo in women with preterm labour (including women with intact membranes and those with ruptured membranes). The research should be conducted through multicentre randomised controlled trials, including some UK centres to allow subgroup analysis of UK data. The primary outcome for evaluating the clinical effectiveness of benzylpenicillin should be the incidence of early-onset neonatal group B streptococcal infection (infection within 72 hours of birth). Secondary outcomes should include long-term outcomes in the baby. The research should include subgroup analyses for women in spontaneous preterm labour with intact membranes and those with membranes that rupture before or during labour.

Source guidance details

Comes from guidance: Antibiotics for early-onset neonatal infection
Number: CG149
Date issued: Aug 2012

Research needed into:

Effectiveness of treatment: No
Cost of treatment: No
Implementation of treatment: No
Quality of life: No
Methods of research: No

Other details

Is this a recommendation for the use of a technology only in the context of research?: No
Is it a recommendation that suggests collection of data or the establishment of a register?: No
Recommendation priority: Unrated
Recommendation status: Research Pending
Notes: 0
Date this record updated: 05-09-2012

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This page was last updated: 20 March 2014

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Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.