notes (if applicable):
|Why this is important:- Previous studies in adults suggest that glucocorticosteroid treatment is more effective at inducing remission than enteral nutrition in adults with Crohn's disease, but some small paediatric studies suggest that growth and mucosal healing may be better following treatment with enteral nutrition. In clinical practice enteral nutrition is often used to avoid the side effects of glucocorticosteroid treatment in children. There is little information about the relative effects on quality of life, bone density or cost effectiveness. Randomised controlled trials should be conducted in children and adults with an inflammatory exacerbation of Crohn's disease to compare the effects of enteral
nutrition and glucocorticosteroid treatment on these parameters and also the effect on growth in
children. Mucosal healing could also be assessed in a subgroup of participants. It is not ethical or
practical to conduct a randomised controlled trial of enteral nutrition versus placebo.