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Summary of Results

Health Topic:   Endocrine, nutritional and metabolic
Guidance:   Obesity - orlistat
Description:   The summary of the withdrawn technology appraisal on Obesity - orlistat. It links to the withdrawn guidance and key documents.

NICE implementation uptake reports

Implementation uptake report Assessment Published Date Coverage

External literature

External literature Assessment Coverage

Johnston A et al (2004) A clinical audit to investigate the compliance of general practitioners to NICE guidelines for the prescribing of anti-obesity drugs sibutramine and orlistat. International Journal of Pharmacy Practice 12: R80.

Description: A clinical audit of orlistat and sibutramine prescribing based on a sample of 490 patient records from thirteen general practices in one primary care trust. The study reported an overall level of compliance with NICE guidance of 60% with wide variation in adherence to the guidance between GP practices.

Doubts about or mixed impact in practice Local

Cullum N, Dawson D, Lankshear A et al. (2004) The Evaluation of the Dissemination, Implementation and Impact of NICE Guidance.

Description: This study used interrupted time series analysis of national prescribing data combined with audit of 689 patient notes from general practice. Prescribing of orlistat significantly increased in line with NICE guidance following publication; the study found significant proportions of patients were being prescribed orlistat without sufficient weight loss as recommended in the guidance, or that results of follow-up were not recorded sufficiently.

Doubts about or mixed impact in practice National

Wathen B et al (2004) An Evaluation of the Impact of NICE Guidance on GP Prescribing. British Journal of General Practice 54: 300-301

Description: This study investigated prescribing expenditure before and after NICE guidance and used data from eighty one postal questionnaires of GPs within a single primary care trust. Qualitative questionnaire feedback included doctors citing patient pressure and practicalities in monitoring weight loss as factors in using the guidance.

Not graded Local

Hayton B (2004) NICE guidance for anti-obesity medication: is it being followed? Journal of Human Nutrition and Dietetics 17: 576-577

Description: A clinical audit of orlistat and sibutramine prescribing based on a sample 154 patient records in a single primary care trust. The study reported that prescribing was not in accordance with NICE guidance.

Practice appears not to be in line with guidance National

Sheldon T, Cullum N, Dawson D, Lankshear A, Lowson K, Watt I, West P, Wright D, & Wright J (2004) What's the evidence that NICE guidance has been implemented? Results from a national evaluation using time series analysis, audit of patients' notes, and interviews British Medical Journal 329:999

Description: This paper is based on the following report also included in ERNIE: Cullum N, Dawson D, Lankshear A et al. (2004) The Evaluation of the Dissemination, Implementation and Impact of NICE Guidance. University of Birmingham: Birmingham.

Not graded National

This page was last updated: 28 August 2007

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Selected, reliable information for health and social care in one place

Accessibility | Cymraeg | Freedom of information | Vision Impaired | Contact Us | Glossary | Data protection | Copyright | Disclaimer | Terms and conditions

Copyright 2014 National Institute for Health and Care Excellence. All rights reserved.