This guideline covers preventing infective endocarditis (IE) in children, young people and adults. It focuses on people at increased risk of infective endocarditis undergoing dental, gastrointestinal tract, genitourinary and respiratory tract procedures.
This guideline includes recommendations on:
- identifying people at increased risk
- patient advice for people at increased risk
- use of antibiotics and mouthwash for people undergoing procedures
- infection control for at risk groups
Who is it for?
- Healthcare professionals
- Children, young people and adults, and their families and carers
Guideline development process
Next review: September 2019
This guideline updates and replaces NICE guideline CG64 (2008). The 2015 update was triggered by a study suggesting that the incidence of infective endocarditis may have been affected by the 2008 guidance. As a precaution, NICE reviewed the evidence relating to the effectiveness of prophylaxis against infective endocarditis and found no need to change any of the existing guidance. In addition, NICE concludes that the longstanding increase in the incidence of infective endocarditis in the UK and other countries globally is not well understood and could be due to a number of factors.
This guideline was previously called prophylaxis against infective endocarditis: antimicrobial prophylaxis against infective endocarditis in adults and children undergoing interventional procedures.
The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The application of the recommendations in this guideline is not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.