NICE has now issued full guidance to the NHS in England, Wales, Scotland and Northern Ireland on allogeneic pancreatic islet cell transplantation for type 1 diabetes mellitus.
This document together with the guidance published on autologous pancreatic islet cell transplantation for improved glycaemic control after pancreatectomy (IPG274) replaces previous guidance IPG13 on pancreatic islet cell transplantation.
Type 1 diabetes mellitus is a condition that occurs when the body does not produce enough insulin (a substance that helps control sugar balance in the body). It is usually treatable with insulin injections, but people with type 1 diabetes mellitus have an increased risk of other health problems, such heart disease. Allogeneic pancreatic islet cell transplantation involves the removal of cells called islet cells, which are responsible for the production of insulin, from human donors. These cells are inserted into the patient's liver to restart insulin production within the body. However, patients who have this procedure will need to take medications to help their bodies' immune system to accept the cells.
This guidance represents the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, healthcare professionals are expected to take this guidance fully into account. However, the guidance does not override the individual responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or guardian or carer.
Commissioners and/or providers have a responsibility to implement the guidance, in their local context, in light of their duties to have due regard to the need to eliminate unlawful discrimination, advance equality of opportunity, and foster good relations. Nothing in this guidance should be interpreted in a way that would be inconsistent with compliance with those duties.
Commissioners and providers have a responsibility to promote an environmentally sustainable health and care system and should assess and reduce the environmental impact of implementing NICE recommendations wherever possible.