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Sepsis

All NICE products on Sepsis. Includes any guidance, advice, NICE Pathways and quality standards.

Sepsis

Everything NICE has said on the recognition, diagnosis and early management of sepsis in an interactive flowchart

NICE Pathway Published July 2016 Last updated April 2019

Sepsis (QS161)

This quality standard covers the recognition, diagnosis and early management of sepsis for all populations. It describes high-quality care in priority areas for improvement.

Quality standard Published September 2017

Neutropenic sepsis

Everything NICE has said on preventing, identifying and managing neutropenic sepsis in children, young people and adults in an interactive flowchart

NICE Pathway Published September 2012 Last updated August 2017

Sepsis: recognition, diagnosis and early management (NG51)

This guideline covers the recognition, diagnosis and early management of sepsis for all populations. The guideline committee identified that the key issues to be included were: recognition and early assessment, diagnostic and prognostic value of blood markers for sepsis, initial treatment, escalating care, identifying the source of infection, early monitoring, information and support for patients and carers, and training and education.

NICE guideline Published July 2016 Last updated September 2017

Neutropenic sepsis: prevention and management in people with cancer (CG151)

This guideline covers preventing, identifying and managing neutropenic sepsis in children, young people and adults receiving treatment for cancer in the community and in secondary and tertiary care. It aims to reduce the risk of infection in people with neutropenia (low number of white blood cells) who are receiving anticancer treatment and improve management of neutropenic sepsis.

Clinical guideline Published September 2012

CytoSorb therapy for sepsis (MIB87)

Advice on the use of CytoSorb therapy for treating sepsis to aid local decision-making

Medtech innovation briefing Published November 2016

Intrapartum care for women with existing medical conditions or obstetric complications and their babies (NG121)

This guideline covers care during labour and birth for women who need extra support because they have a medical condition or complications in their current or previous pregnancy. The guideline also covers women who have had no antenatal care. It aims to improve experiences and outcomes for women and their babies.

NICE guideline Published March 2019 Last updated April 2019

Procalcitonin testing for diagnosing and monitoring sepsis (ADVIA Centaur BRAHMS PCT assay, BRAHMS PCT Sensitive Kryptor assay, Elecsys BRAHMS PCT assay, LIAISON BRAHMS PCT assay and VIDAS BRAHMS PCT assay) (DG18)

Evidence-based recommendations on procalcitonin testing for diagnosing and monitoring sepsis (AVIDA Centaur BRAHMS PCT assay, BRAHMS PCT Sensitive..

Diagnostics guidance Published October 2015

Pyelonephritis (acute): antimicrobial prescribing (NG111)

This guideline sets out an antimicrobial prescribing strategy for acute pyelonephritis (upper urinary tract infection) in children, young people and adults who do not have a catheter. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published October 2018

Intrapartum care for women with obstetric complications

Everything NICE has said on intrapartum care for women with obstetric complications in an interactive flowchart

NICE Pathway Published March 2019 Last updated September 2019

Urinary tract infection (catheter-associated): antimicrobial prescribing (NG113)

This guideline sets out an antimicrobial prescribing strategy for catheter-associated urinary tract infection in children, young people and adults. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published November 2018

Developmental follow-up of children and young people born preterm (NG72)

This guideline covers the developmental follow-up of babies, children and young people under 18 years who were born preterm (before 37+0 weeks of pregnancy). It explains the risk of different developmental problems and disorders, and specifies what extra assessments and support children born preterm might need during their growth and development.

NICE guideline Published August 2017

Prostatitis (acute): antimicrobial prescribing (NG110)

This guideline sets out an antimicrobial prescribing strategy for acute prostatitis. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published October 2018

Acute kidney injury: prevention, detection and management (CG169)

This guideline covers preventing, detecting, and managing acute kidney injury in children (aged above 1 month and below 12 years), young people (aged 12 to 17 years) and adults (aged 18 years or older). It aims to improve assessment and detection by non-specialist clinicians, and specifies when they should refer people to specialist services. This will reduce the chance of death or complications for people at risk of acute kidney injury.

Clinical guideline Published August 2013

Inducing labour (CG70)

This guideline covers circumstances, methods and monitoring for inducing labour in pregnant women to avoid a pregnancy lasting longer than 42 weeks (known as a prolonged pregnancy) or if a woman’s waters break but labour does not start. It aims to improve the advice and care provided to women considering and undergoing induction of labour in hospital-based maternity units, midwifery led units and at home .

Clinical guideline Published July 2008

Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing (NG117)

This guideline sets out an antimicrobial prescribing strategy for managing and preventing acute exacerbations of bronchiectasis (non-cystic fibrosis). It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published December 2018

Tests for rapidly identifying bloodstream bacteria and fungi (LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay) (DG20)

Evidence-based recommendations on the LightCycler SeptiFast Test MGRADE, SepsiTest and IRIDICA BAC BSI assay for identifying bloodstream bacteria and fungi

Diagnostics guidance Published February 2016

Urinary tract infections

Everything NICE has said on diagnosing, treating and managing urinary tract infections including lower (cystitis), upper (acute pyelonephritis) and recurrent UTIs in people with or without a catheter in an interactive flowchart

NICE Pathway Published August 2012 Last updated September 2019

Pneumonia (hospital-acquired): antimicrobial prescribing (NG139)

This guideline sets out an antimicrobial prescribing strategy for adults, young people, children and babies aged 72 hours and over with a confirmed diagnosis of hospital-acquired pneumonia. It does not cover ventilator-associated pneumonia. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published September 2019

Pneumonia (community-acquired): antimicrobial prescribing (NG138)

This guideline sets out an antimicrobial prescribing strategy for adults, young people, children and babies aged 72 hours and over with a confirmed diagnosis of community-acquired pneumonia. It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published September 2019

Fever in under 5s: assessment and initial management (CG160)

This guideline covers the assessment and early management of fever with no obvious cause in children aged under 5. It aims to improve clinical assessment and help healthcare professionals diagnose serious illness among young children who present with fever in primary and secondary care.

Clinical guideline Published May 2013 Last updated August 2017

Pneumonia

Everything NICE has said on diagnosing and managing community- and hospital-acquired pneumonia in an interactive flowchart

NICE Pathway Published December 2014 Last updated September 2019

Intravenous fluid therapy in adults in hospital (CG174)

This guideline covers the general principles for managing intravenous (IV) fluid therapy in hospital inpatients aged 16 and over with a range of conditions. It aims to help prescribers understand the optimal amount and composition of IV fluids to be administered and the best rate at which to give them, to improve fluid prescribing and outcomes among people in hospital. It does not cover pregnant women, and those with severe liver or renal disease, diabetes or burns.

Clinical guideline Published December 2013 Last updated May 2017

NICE impact: antimicrobial resistance

How NICE recommendations are being used to slow the emergence of antimicrobial resistance

Published November 2018 Last updated November 2018

Antimicrobial stewardship

Everything NICE has said on effective antimicrobial medicine use and preventing the spread of resistant microbes in an interactive flowchart

NICE Pathway Published August 2015 Last updated June 2019

Haematological cancers: improving outcomes (NG47)

This guideline covers integrated diagnostic reporting for diagnosing haematological cancer in adults, young people and children. It also covers staffing, facilities (levels of care) and multidisciplinary teams needed for adults and young people. It aims to improve care for people with suspected or diagnosed cancer by promoting best practice on the organisation of haematological cancer services.

NICE guideline Published May 2016

Therapeutic hypothermia following cardiac arrest (IPG386)

Evidence-based recommendations on therapeutic hypothermia following cardiac arrest

Interventional procedures guidance Published March 2011

Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing (NG114)

This guideline sets out an antimicrobial prescribing strategy for acute exacerbations of chronic obstructive pulmonary disease (COPD). It aims to optimise antibiotic use and reduce antibiotic resistance.

Antimicrobial prescribing guideline Published December 2018

Negative pressure wound therapy for the open abdomen (IPG467)

Evidence-based recommendations on negative pressure (vacuum therapy) wound therapy for the open (exposed) abdomen to aid healing

Interventional procedures guidance Published November 2013

Extracorporeal membrane oxygenation (ECMO) for acute heart failure in adults (IPG482)

Evidence-based recommendations on extracorporeal membrane oxygenation (artificial lung) for acute heart failure in adults

Interventional procedures guidance Published March 2014

Endo-SPONGE for colorectal anastomotic leakage (MIB188)

Advice on the use of Endo-SPONGE for colorectal anastomotic leakage to aid local decision making

Medtech innovation briefing Published August 2019

Serial transverse enteroplasty procedure (STEP) for bowel lengthening in parenteral nutrition-dependent children (IPG232)

Evidence-based recommendations on serial transverse enteroplasty procedure (STEP) for bowel lengthening in children with short bowel syndrome (SBS)

Interventional procedures guidance Published September 2007

Gallstone disease

Everything NICE has said on diagnosing and managing gallstone disease in adults in an interactive flowchart

NICE Pathway Published October 2014 Last updated March 2017

Diabetic foot problems: prevention and management (NG19)

This guideline covers preventing and managing foot problems in children, young people and adults with diabetes. The guideline aims to reduce variation in practice.

NICE guideline Published August 2015 Last updated January 2016

Artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure (IPG602)

Evidence-based recommendations on artificial heart implantation as a bridge to transplantation for end-stage refractory biventricular heart failure

Interventional procedures guidance Published December 2017

Epidemiological study on presentation and management of sepsis in England:- What is the incidence, presentation and management of sepsis in the United Kingdom?

study on presentation and management of sepsis in England:- What is the incidence, presentation and management of sepsis in...

Research recommendation Published August 2016

The NGAL Test for early diagnosis of acute kidney injury (MIB3)

Advice on the use of the NGAL Test for early diagnosis of acute kidney injury (AKI) to aid local decision-making

Medtech innovation briefing Published February 2014

Transforming urgent and emergency care

How NICE resources can support local priorities

Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management (CG102)

This guideline covers recognising, diagnosing and managing bacterial meningitis and meningococcal septicaemia (blood poisoning) in babies, children and young people under 16. It aims to reduce deaths and disability by promoting early recognition of symptoms and timely effective management.

Clinical guideline Published June 2010 Last updated February 2015

Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition (CG32)

This guideline covers identifying and caring for adults who are malnourished or at risk of malnutrition in hospital or in their own home or a care home. It offers advice on how oral, enteral tube feeding and parenteral nutrition support should be started, administered and stopped. It aims to support healthcare professionals identify malnourished people and help them to choose the most appropriate form of support.

Clinical guideline Published February 2006 Last updated August 2017

Faecal microbiota transplant for recurrent Clostridium difficile infection (IPG485)

Evidence-based recommendations on faecal microbiota (bacteria) transplant for recurrent Clostridium difficile (C. difficile/C. diff) infection

Interventional procedures guidance Published March 2014

Fever in under 5s

Everything NICE has said on assessing and initiating management of fever with no obvious cause in children under 5 in an interactive flowchart

NICE Pathway Published May 2013 Last updated October 2018

HumiGard for preventing inadvertent perioperative hypothermia (MTG31)

Evidence-based recommendations on HumiGard for preventing inadvertent perioperative hypothermia in patients having abdominal surgery

Medical technologies guidance Published February 2017

Bronchiectasis (non-cystic fibrosis) – antimicrobial prescribing

Everything NICE has said on antimicrobial prescribing for managing and preventing an acute exacerbation of bronchiectasis (non-cystic fibrosis) in an interactive flowchart

NICE Pathway Published December 2018 Last updated September 2019

Chronic heart failure in adults: diagnosis and management (NG106)

This guideline covers diagnosing and managing chronic heart failure in people aged 18 and over. It aims to improve diagnosis and treatment to increase the length and quality of life for people with heart failure.

NICE guideline Published September 2018

i STAT CG4+ and CHEM8+ cartridges for point-of-care testing in the emergency department (MIB38)

Advice on the use of the i STAT CG4+ and CHEM8+ cartridges for point-of-care testing in the emergency department to aid local decision-making

Medtech innovation briefing Published September 2015

Nutrition support in adults

Everything NICE has said on nutrition support for adults who are malnourished or at risk of malnutrition in an interactive flowchart

NICE Pathway Published November 2012 Last updated August 2017

Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort study should be carried out to assess the incidence of suspected and proven neutropenic sepsis in patients having anticancer treatment.

Recommendation ID CG151/1 Question Service provision for neutropenic sepsis in patients with cancer:- A prospective national cohort...

Research recommendation Published June 2015