Recommendation ID

Probiotic and prebiotic supplements:- What is the clinical and cost effectiveness of probiotics or prebiotics to treat NAFLD in adults, young people and children?

Any explanatory notes
(if applicable)

Why this is important:- NAFLD is the most common metabolic liver disease, occurring in approximately 30% of all adults, around 46% of obese people and around 53% of people with type 2 diabetes. Liver fat accumulation is the first stage of more serious chronic liver disease in NAFLD. A small body of evidence supports the use of probiotics in NAFLD but the data are inconclusive and high-quality double-blind randomised placebo-controlled trials are needed. The evidence from cross-sectional studies suggests associations between unfavourable disturbance in gut microbiota and obesity or type 2 diabetes, but there is very limited evidence on whether modifying the gut microbiota influences NAFLD.

Source guidance details

Comes from guidance
Non-alcoholic fatty liver disease (NAFLD): assessment and management
Date issued
July 2016

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 31/07/2016