Recommendation ID

NICE agreed that further research would be of value to investigate factors which can predict the likelihood of rapid progression of disease and response to treatment with biological DMARDs. Factors to investigate include:
- persistent elevation of inflammatory markers (such as C-reactive protein [CRP]) and
- presence of erosions on X-ray and
- positive for anti-citrullinated protein antibodies (ACPA).

Any explanatory notes
(if applicable)

The NICE Committee felt that how these factors interact with each other and to what extent the likelihood of progression is affected by the use of different thresholds would be of value.

Source guidance details

Comes from guidance
Adalimumab, etanercept, infliximab, certolizumab pegol, golimumab, tocilizumab and abatacept for rheumatoid arthritis not previously treated with DMARDs or after conventional DMARDs only have failed
Date issued
January 2016

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 31/01/2016