Recommendation ID
CG117/2
Question
Directly observed therapy:- A cluster randomised controlled trial of directly observed therapy (DOT) compared with self-administered treatment for latent and/or active tuberculosis (TB) should be conducted in a UK population. This should be targeted at homeless people, and those with a history of non-adherence, alcoholism, drug abuse or mental illness.
Any explanatory notes
(if applicable)
Why this is important:- There is currently no evidence from controlled studies on the use of directly observed therapy (DOT) in the UK. If a UK programme of DOT is found to promote adherence to treatment in these populations, then patients would be less likely to experience future relapse or drug resistance, or to transmit tuberculosis (TB) to other patients.

Source guidance details

Comes from guidance
Tuberculosis: clinical diagnosis and management of tuberculosis, and measures for its prevention and control
Number
CG117
Date issued
March 2011

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No