- Recommendation ID
- Newly diagnosed seizures (focal and generalised) – monotherapy: How do the newer AEDs compare in efficacy to the standard anti-epileptic drugs (AEDs) in the treatment of newly diagnosed epilepsy?
- Focal seizures: carbamazepine, eslicarbazepine acetate, lacosamide, lamotrigine, levetiracetam, pregabalin and zonisamide.
- Generalised seizures: lamotrigine, levetiracetam, sodium valproate and zonisamide.
- Any explanatory notes
- Why this is important:- Levetiracetam and other anti-epileptic drugs (AEDs) licensed for the treatment of focal and generalised seizures since publication of the original guideline The epilepsies (NICE clinical guideline 20) in 2004 have not been evaluated as first-line monotherapy.
The research should include:
- a prospective randomised controlled trial all age groups
- subgroup analyses on seizure types and syndromes
- primary outcome of seizure freedom
- secondary outcomes, including seizure reduction, quality of life and cognitive outcome
- an attempt to obtain data on pharmaco-resistance.
Source guidance details
- Comes from guidance
- Epilepsies: diagnosis and management
- Date issued
- January 2012
|Is this a recommendation for the use of a technology only in the context of research?||No|
|Is it a recommendation that suggests collection of data or the establishment of a register?||No|