Recommendation ID
CG137/2
Question
Epilepsy syndromes:- What are the initial and add-on anti-epileptic drugs (AEDs) of choice in the treatment of the epilepsy syndromes with onset in childhood, for example, myoclonic-astatic epilepsy and Dravet syndrome?
Any explanatory notes
(if applicable)
Why this is important:- Despite the need to diagnose individual epilepsy syndromes, there is little evidence on the most appropriate initial or add-on anti-epileptic drugs (AEDs) in the treatment of the rarer epilepsies.
The research should include:
- multicentre randomised controlled comparative trials with centralised national data collection
- the ketogenic diet as one of the randomised treatments
- primary outcome of seizure freedom
- secondary outcomes, including seizure reduction, quality of life and cognitive outcome
- an attempt to obtain data on pharmaco-resistance
- the possibility of including all children with specific epilepsy syndromes for consideration in the trial.

Source guidance details

Comes from guidance
Epilepsies: diagnosis and management
Number
CG137
Date issued
January 2012

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No