Recommendation ID
CG149/3
Question
Intrapartum antibiotic prophylaxis in preterm labour:- What is the clinical and cost effectiveness of intrapartum antibiotic prophylaxis using benzylpenicillin in women with preterm labour?
Any explanatory notes
(if applicable)
Why this is important:- In the absence of unequivocal evidence of clinical and cost effectiveness of intrapartum antibiotic prophylaxis to prevent early-onset neonatal infection in the babies of all women with preterm labour, the recommendation to consider intrapartum antibiotic prophylaxis for women with preterm labour and either prelabour rupture of membranes or confirmed or suspected rupture of membranes of 18 hours' duration or longer was based on the Guideline Development Group's consensus view and knowledge of current practice.
Further research is needed to evaluate the clinical and cost effectiveness of intrapartum
antibiotic prophylaxis using benzylpenicillin compared with placebo in women with preterm labour
(including women with intact membranes and those with ruptured membranes). The research
should be conducted through multicentre randomised controlled trials, including some UK
centres to allow subgroup analysis of UK data. The primary outcome for evaluating the clinical
effectiveness of benzylpenicillin should be the incidence of early-onset neonatal group B
streptococcal infection (infection within 72 hours of birth). Secondary outcomes should include
long-term outcomes in the baby. The research should include subgroup analyses for women in
spontaneous preterm labour with intact membranes and those with membranes that rupture
before or during labour.

Source guidance details

Comes from guidance
Neonatal infection (early onset): antibiotics for prevention and treatment
Number
CG149
Date issued
August 2012

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 03/09/2012