Recommendation ID
CG149/5
Question
Duration of antibiotic treatment:- What is the optimal duration of treatment (course length) in babies who receive antibiotics for confirmed early-onset neonatal infection?
Any explanatory notes
(if applicable)
Why this is important:- The Guideline Development Group identified no evidence to inform the choice of duration of antibiotic treatment (course length) for confirmed early-onset neonatal infection. In the absence of evidence, the Guideline Development Group based its recommendations on its knowledge of current clinical practice. Further research is needed to evaluate different course lengths in the following clinical circumstances:
- babies with group B streptococcal bacterial meningitis
- babies with group B streptococcal septicaemia
- babies with Gram-negative bacterial meningitis (such as Escherichia coli meningitis)
- babies with Gram-negative septicaemia.
The research should ideally take the form of multinational randomised controlled trials. The primary outcome should be relapse within 10 days of stopping treatment. Secondary outcomes should include long-term neurodevelopment.

Source guidance details

Comes from guidance
Neonatal infection (early onset): antibiotics for prevention and treatment
Number
CG149
Date issued
August 2012

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 03/09/2012