Recommendation ID
CG157/1
Question
Phosphate binders in adults with chronic kidney disease (CKD) stage 4 or 5:- Which binders are most effective in controlling serum phosphate in adults with stage 4 or 5 CKD who are not on dialysis?
Any explanatory notes
(if applicable)
Why this is important:- Limited evidence was found on the use of phosphate binders in adults with stage 4 or 5 chronic kidney disease (CKD). While it is possible in some instances to extrapolate from the evidence on people with stage 5 CKD who are on dialysis, it is not ideal. Therefore, a series of RCTs should be conducted to examine the comparative effectiveness of various phosphate binders against each other for the management of serum phosphate in adults with stage 4 or 5 CKD. These trials should examine the long-term (ideally 12-month) effects of the various binders on outcomes such as serum phosphate, serum calcium, adverse events and the ability of the binders to control serum phosphate and calcium within the given ranges.

Source guidance details

Comes from guidance
Chronic kidney disease (stage 4 or 5): management of hyperphosphataemia
Number
CG157
Date issued
March 2013

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 27/03/2013