Recommendation ID
CG157/4
Question
Phosphate binders in children Which binders are most effective in controlling serum phosphate in children with stage 4 or 5 chronic kidney disease (CKD), including those who are on dialysis?
Any explanatory notes
(if applicable)
Why this is important:- Limited evidence was found on the use of phosphate binders in children with stage 5 chronic kidney disease (CKD) who are on dialysis, and none was found for those with stage 4 or 5 CKD who are not on dialysis. Therefore, a series of RCTs should be conducted that examine the comparative effectiveness of various phosphate binders against each other for the management of serum phosphate. These RCTs should be conducted separately in those with stages 4 or 5 CKD who are not on dialysis and those with stage 5 who are on dialysis. These trials should examine the long-term (ideally 12-month) effects of the various binders on outcomes such as serum phosphate, serum calcium, adverse events and the ability of the binders to control serum phosphate and calcium within the given ranges, as well as the most appropriate sequencing of binders.

Source guidance details

Comes from guidance
Chronic kidney disease (stage 4 or 5): management of hyperphosphataemia
Number
CG157
Date issued
March 2013

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 27/03/2013