Recommendation ID
Symptoms and signs of serious illness: - NICE recommends a UK-based epidemiological study on the symptoms and signs of serious illness. [new 2013]
Any explanatory notes
(if applicable)
Why this is important:- The current recommendations on symptoms and signs in the NICE guideline are based on a series of heterogeneous studies (using different methods, populations, outcomes and of varying quality) and a degree of subjectivity was needed to bring these together in the guideline. Therefore, the NICE recommends that a large prospective UK-wide study (n=20,000 plus) should be undertaken comparing all of these symptoms and signs covered in the guideline. This would allow for a standardised comparison of each symptom and sign, and for validation of the existing 'traffic light' table.
The study should use a standardised data collection protocol. Where possible the study should link with routinely collected data sets, such as Hospital Episode Statistics. The study should include a variety of settings and locations – that is, wherever children present, including primary care. The primary outcome of the study should be the final diagnosis and results of treatment.

Source guidance details

Comes from guidance
Fever in under 5s: assessment and initial management
Date issued
May 2013

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 13/06/2013