Recommendation ID
CG166/2
Question
Induction of remission for people with moderate ulcerative colitis: prednisolone compared with
beclometasone:- What is the clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone plus an aminosalicylate for induction of remission for people with moderate ulcerative colitis?
Any explanatory notes
(if applicable)
Why this is important:- Evidence exists about the effectiveness of beclometasone plus an aminosalicylate for induction of remission in people with moderate ulcerative colitis. It seems likely that any corticosteroid would have a similar effect to beclometasone (in combination with an aminosalicylate), but no evidence was available to confirm this. Prednisolone is cheap and readily available. Evidence to show comparable or better clinical and cost effectiveness of prednisolone plus an aminosalicylate compared with beclometasone plus an aminosalicylate would represent a significant cost benefit and potentially increased or at least similar clinical efficacy. The research should take the form of a double-blind randomised controlled trial. The outcomes should include patient satisfaction measures.

Source guidance details

Comes from guidance
Ulcerative colitis: management
Number
CG166
Date issued
June 2013

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 15/07/2013