Recommendation ID
NICE recommends further research comparing the clinical effectiveness of different early rule-out test protocols using high-sensitivity assays which meet the criteria applied for this assessment. NICE recommends that future studies should include consideration of the clinical effectiveness of different test strategies including those employing low diagnostic thresholds, and the impact of different test strategies on both clinician behaviour and the health system, with a view to reducing uncertainty in the economic model. Future studies should also investigate the role of sex and age-specific 99th percentile thresholds in the assessment of suspected acute coronary syndrome. The Committee also considered that it would be appropriate to include adjudication with high-sensitivity troponin assays at time points earlier than 10–12 hours as the reference standard in future studies.
Any explanatory notes
(if applicable)

Source guidance details

Comes from guidance
Myocardial infarction (acute): Early rule out using high-sensitivity troponin tests (Elecsys Troponin T high-sensitive, ARCHITECT STAT High Sensitive Troponin-I and AccuTnI+3 assays)
Date issued
October 2014

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 27/11/2014