Individual research recommendation details

Recommendation ID

MTG60/01

Question

A randomised controlled trial is recommended to compare DyeVert Systems with standard care. The aim of this research would be to address uncertainties about whether using DyeVert Systems reduces AKI incidence and rate of renal replacement therapy after using contrast media. This must include people with stage 4 chronic kidney disease (with an estimated glomerular filtration rate [eGFR] under 30 ml/min/1.73 m2), who are at risk of AKI and need elective coronary or peripheral angiography.

Any explanatory notes
(if applicable)

Further good-quality research is needed to address uncertainties about the clinical efficacy of DyeVert Systems. The committee concluded that further research is needed to address uncertainties in the clinical effectiveness of DyeVert Systems compared with standard care. It concluded that, although there is clear evidence that DyeVert Systems can reduce contrast volume received while maintaining image quality, the evidence around AKI incidence was weaker. The committee concluded that a randomised controlled trial was needed. It should collect data on AKI incidence, renal replacement therapy, hospital stay, and biochemical markers of kidney injury, and should follow up for enough time to capture these outcomes. The population must include people having an elective coronary or peripheral angiography procedure who have an eGFR less than 30 ml/min/1.73 m2. Further evidence should be collected to resolve the uncertainties around the generalisability between the 2 DyeVert devices. The committee noted that collecting evidence for DyeVert in peripheral angiography will be more difficult because of the different ways the procedure is done. It concluded that for peripheral angiography, it may be appropriate to trial the system in procedures that use a consistent volume of contrast, such as endovascular aneurysm repair.

Source guidance details

Comes from guidance

DyeVert Systems for reducing the risk of acute kidney injury in coronary and peripheral angiography

Number

MTG60

Date issued

October 2021

Other details