Recommendation ID

Vitamin D supplementation:- In people with stage I–III melanoma does vitamin D supplementation improve overall survival?
This should be investigated in a placebo-controlled randomised trial. Secondary outcomes should include disease-specific survival and toxicity, including the development of renal stones and hypercalcaemia.

Any explanatory notes
(if applicable)

Why this is important:- It has been reported that suboptimal levels of vitamin D at diagnosis are common in people with melanoma from the north of England and that higher levels are associated with lower melanoma-related mortality. However, vitamin D levels are higher in leaner, fitter people and the nature of the relationship between vitamin D levels and melanoma survival is unclear.
There are 2 adjuvant trials of vitamin D supplementation listed as active currently, 1 in Italy and 1 in Australia. However, there are many uncertainties about the design of vitamin D trials, which might become clearer in the next few years. These include the dose of vitamin D, use of concurrent aspirin therapy and the baseline level at which vitamin D supplementation would be started.

Source guidance details

Comes from guidance
Melanoma: assessment and management
Date issued
July 2015

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No