Recommendation ID
NG28/3
Question

Drug treatment (third intensification) for when blood glucose levels are inadequately controlled by 3 oral antidiabetic drugs and/or insulin combinations:- When third intensification of treatment is indicated, which blood glucose lowering therapies should be used to control blood glucose levels?

Any explanatory notes
(if applicable)

Why this is important:- As the incidence of type 2 diabetes increases in the younger population and as blood glucose control declines naturally over time, it is likely that further intensification of therapies would be needed. Currently, there is evidence up to second intensification of drug therapies, that is, when 2 or more non-insulin-based treatment combinations fail to adequately control blood glucose levels. Randomised controlled trials are needed to improve understanding of alternative treatment options for adults at second intensification whose blood glucose is inadequately controlled with insulin and/or triple non-insulin-based drug therapies.


Source guidance details

Comes from guidance
Type 2 diabetes in adults: management
Number
NG28
Date issued
December 2015

Other details

Is this a recommendation for the use of a technology only in the context of research? No  
Is it a recommendation that suggests collection of data or the establishment of a register?   No  
Last Reviewed 31/12/2015