- Recommendation ID
- NG85/4
- Question
Pain management:- A randomised trial should be undertaken comparing early endoscopic ultrasound-guided neurolytic coeliac plexus (EUS-guided NCP) interventions with on-demand EUS-guided NCP interventions in people with unresectable pancreatic cancer.
- Any explanatory notes
(if applicable) Why this is important:- There is a limited number of randomised trials in this area, and the methods used to perform NCP intervention are heterogeneous. It is not clear if early NCP intervention is superior to on-demand NCP intervention in terms of the important outcomes for the patient and duration of effect of the procedure. On-demand NCP intervention may benefit people with uncontrolled pain, people receiving escalating doses of analgesia, people experiencing unacceptable analgesic side effects, and others. However, people who receive early NCP intervention may not need on-demand NCP intervention later on. Further research should clarify if the timing of the intervention confers any advantage. The outcomes of interest are:
- reduction in pain
- patient experience (including nutritional status)
- health-related quality of life
- adverse events
- analgesic use
- survival.
Source guidance details
- Comes from guidance
- Pancreatic cancer in adults: diagnosis and management
- Number
- NG85
- Date issued
- February 2018
Other details
| Is this a recommendation for the use of a technology only in the context of research? | No |
| Is it a recommendation that suggests collection of data or the establishment of a register? | No |
| Last Reviewed | 28/02/2018 |