Evidence strengths and limitations

Evidence strengths and limitations

The evidence for use of tranexamic acid for significant haemorrhage following trauma comes from a large high-quality RCT with a relatively low risk of bias[21].

  • The CRASH-2 RCT was well-conducted study with more than 99% of patients followed up and high internal validity.

  • Participants in the trial were appropriately randomised with allocation concealed and assessors and patients all blinded to treatment group.



[21] Roberts I, Shakur H, Ker K et al. (2011) Antifibrinolytic drugs for acute traumatic injury (Review). The Cochrane Collaboration 1.