References

References

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CRASH-2 trial collaborators. (2010) Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 376: 23–32.

CRASH-2 trial collaborators. (2011) The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet 377: 1096–101.

Electronic Medicines Compendium (eMC). Summary of Product Characteristics: Tranexamic acid. Available from: www.medicines.org.uk [Accessed on 24 September 2012]

Guerriero C, Cairns J, Perel P et al. (2011) Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS one; 6(5).

Ker K, Kiriya J, Perel P et al. (2012) Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial. BMC Emergency Medicine 12(3).

Perel P, Prieto-Merino D, Shakur H et al. Predicting early death in patients with traumatic bleeding: development and validation of prognostic model. (2012) BMJ 345: e5166.

Roberts I, Perel P, Prieto-Merino D et al. (2012) Effects of tranexamic acid on mortality in patients with traumatic bleeding: prespecified analysis of data from randomised controlled trial. BMJ 345: e5839.

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