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This information explains the evidence summary about the off-label use of misoprostol (inserted into the vagina) after oral mifepristone for the induction of labour (starting labour artificially) following the late death of an unborn baby (fetus) in the womb (known as late intrauterine fetal death). In this context, 'late' means the woman is 24 weeks pregnant or more. The evidence summary is an overview of the available information about this medicine. It aims to help prescribers and patients when they are considering whether or not to use an unlicensed or off-label treatment.
If a woman's baby has died in the womb after 24 weeks of pregnancy or more, 1 option that NICE recommends is kick-starting labour using a drug called mifepristone, followed by a drug called a prostaglandin. Misoprostol is a type of prostaglandin. The evidence summary looks at the risks and benefits of misoprostol, particularly the differences between high doses and low doses of this medicine.