Antimicrobial resistance poses a significant global threat to public health, especially because antibiotics underpin routine medical practice. In response, the World Health Organisation (WHO) has developed a global action plan on antimicrobial resistance. The Chief Medical Officer's report on the threat of antimicrobial resistance and infectious diseases (2013) highlights that, although a new infectious disease has been discovered nearly every year for the past 30 years, there have been very few new antimicrobials developed. This is leaving the armoury nearly empty as diseases evolve and become resistant to existing antimicrobials. The report highlights that looking after the current supply of antimicrobials is equally as important as encouraging development of new drugs.
A practical example of this is given in the English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) report 2018. This states that the proportions of bacterial species causing bloodstream infections that are resistant to key antibiotics have remained stable over the last 5 years probably because of more effective antimicrobial stewardship. However, the estimated total numbers caused by pathogens resistant to 1 or more key antibiotics has increased from 12,250 in 2013 to 16,504 in 2017, a rise of 35%, in particular those caused by Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae). The 2018 ESPAUR report stated that the proportion of E. coli bloodstream infections non-susceptible to piperacillin/tazobactam (the most frequently used antibiotic for the treatment of sepsis) increased year on year between 2013 and 2017, from 10.6% to 15.3%. For K. pneumoniae bloodstream infections non-susceptible to piperacillin/tazobactam, there was an increase between 2013 and 2017 from 16.4% to 19.4%. The 2016 ESPAUR report states that increases in resistance to piperacillin/tazobactam will increase the pressure on clinicians to use carbapenems (which are the antibiotics of last resort) unless alternative treatment strategies are developed.
For some other bacteria where there have been targeted interventions to reduce the burden of infection or resistance, infection rates or proportions of infections where resistance is detected have declined. For example, according to the ESPAUR report 2018, methicillin-resistant Staphylococcus aureus bloodstream infections continued to decline year on year from 9.5% in 2012/13 to 6.6% in 2017/18 through effective infection prevention and control within healthcare settings.
NICE has published a guideline on antimicrobial stewardship: systems and processes for effective antimicrobial medicine use. This recommends that commissioners should ensure that antimicrobial stewardship operates across all care settings. They should consider including the following in their antimicrobial stewardship programme:
monitoring and evaluating antimicrobial prescribing and how this relates to local resistance patterns
providing regular feedback to individual prescribers in all care settings about their antimicrobial prescribing and patient safety incidents related to antimicrobial use
providing education and training to health and social care practitioners about antimicrobial stewardship and antimicrobial resistance
integrating audit into existing quality improvement programmes.
The national antimicrobial prescribing and stewardship competencies for prescribers aim to improve the quality of antimicrobial treatment and stewardship and so reduce the risks of inadequate, inappropriate and ill-effects of treatment. They complement the national generic prescribing competency framework. Regulators, education providers and professional bodies can also use them to inform the development of standards, guidance and training.
The WHO has also identified that improving awareness and understanding of antimicrobial resistance through effective communication, education and training is critical to tackling this issue. NICE has published a guideline on antimicrobial stewardship: changing risk-related behaviours in the general population. Public Health England (PHE) has published an antimicrobial resistance resource handbook, which collates national resources on antimicrobial resistance, antimicrobial stewardship and infection prevention and control. NHS England has also collated information on addressing antimicrobial resistance. Resources include 2 national toolkits to support implementation of antimicrobial stewardship best practice: the TARGET antibiotics toolkit for primary care and Start smart – then focus for secondary care. A dental antimicrobial stewardship toolkit is also available.
The ESPAUR report 2018 states that almost 58,000 people from 129 countries have become Antibiotic Guardians. Becoming an Antibiotic Guardian involves pledging an action to reduce the unnecessary use of antimicrobials and is open to members of the public and healthcare professionals. PHE has also launched the national public campaign, Keep Antibiotics Working, to support the government's efforts to reduce inappropriate prescriptions for antibiotics by raising awareness of the issue of antibiotic resistance and reducing demand from the public. Addressing antimicrobial resistance through improving stewardship is a national medicines optimisation priority, led by NHS England and supported by PHE and the work of the Regional Medicines Optimisation Committees (RMOCs).
The Department of Health and Social Care has commissioned NICE, in collaboration with PHE, to develop clinical syndrome-specific guidance and advice, which offer evidence-based antimicrobial prescribing information for all care settings to help slow the development of antimicrobial resistances.
To help prevent the development of resistance, it is important to prescribe antibiotics only when they are necessary, and not for self-limiting mild respiratory infections such as colds and most coughs, sinusitis, earache and sore throats. For example, the NICE antimicrobial prescribing guideline on acute sinusitis recommends no antibiotics for people presenting with symptoms for around 10 days or less.
NICE recommends that in most cases, consideration should be given to a no, or back-up (delayed) antibiotic strategy for people with acute self-limiting upper respiratory tract infections, such as in people with acute cough, sore throat and otitis media. An immediate antibiotic prescription is still appropriate in some situations (see the individual guidelines for further information).
NICE recommends that people should be given supporting information about antibiotic strategies, infection severity and usual duration, such as the PHE leaflet on managing your infection. NICE has also published a suite of antimicrobial prescribing guidelines on urinary tract infections (UTIs). PHE has produced guidance for primary care on diagnosing UTI and understanding culture results.
When antimicrobials are necessary to treat an infection that is not life-threatening, a narrow-spectrum antibiotic should generally be first choice. Indiscriminate use of broad-spectrum antibiotics creates a selective advantage for bacteria resistant even to these 'last-line' broad-spectrum agents, and also kills normal commensal flora leaving people susceptible to antibiotic-resistant harmful bacteria such as Clostridium difficile (C. difficile). For infections that are not life-threatening, broad-spectrum antibiotics (for example, co-amoxiclav, quinolones and cephalosporins) need to be reserved for second-choice treatment when narrow-spectrum antibiotics are ineffective (Chief Medical Officer Annual report 2011).
The Advisory Committee on Antimicrobial Prescribing, Resistance and Healthcare Associated Infection (APRHAI) recommends the Start smart − then focus approach. This advises that, if immediate antibiotic treatment is necessary, the clinical diagnosis and continuing need for antibiotics should be reviewed within 48 to 72 hours. A study of Start smart − then focus, which was discussed in NICE's eyes on evidence article on implementation of antibiotic prescribing guidance, concluded that most hospital antibiotic policies in England 'start smart' by recommending broad-spectrum antibiotics for empirical therapy in severe infections. However, fewer hospital antibiotic policies 'focus' by reviewing the ongoing need for antibiotics after a couple of days, as recommended.
See the March 2019 edition of Drug Safety Update for the most recent information. A number of safety issues with fluoroquinolone and quinolone antibiotics have been raised. For example, in the November 2018 edition of Drug Safety Update, the Medicines and Healthcare products Regulatory Agency (MHRA) highlighted a small increased risk of aortic aneurysm and dissection with systemic and inhaled fluoroquinolones, and recommended caution and advice for prescribing in people with a high risk. The European Medicines Agency (EMA) Pharmacovigilance Risk Assessment Committee (PRAC) has recommended restricting the use of certain antibiotics following a review into the safety of quinolones and fluoroquinolones. The review found that very rarely, people having treatment with these antibiotics reported long-lasting and disabling side effects, mainly involving muscles, tendons and bones and the nervous system. Subsequently, the EMA's Committee for Medicinal Products for Human Use (CHMP) endorsed the recommendations of the PRAC and concluded that the marketing authorisation of medicines containing nalidixic acid (and cinoxacin, flumequine and pipemidic acid, which do not have UK marketing authorisations) should be suspended. This is because they are authorised only for infections that should no longer be treated with this class of antibiotics. The CHMP recommended that the remaining fluoroquinolone antibiotics (such as ciprofloxacin, levofloxacin, moxifloxacin and ofloxacin) should not be used:
to treat self-limiting infections, or infections that are not severe (such as throat infections)
to treat non-bacterial infections, for example, non-bacterial (chronic) prostatitis
to prevent traveller's diarrhoea or recurring lower UTIs
to treat mild or moderately severe infections unless other antibacterial medicines commonly recommended for these infections cannot be used.
Fluoroquinolone antibiotics should be avoided when treating infections in people who have previously experienced serious adverse events with fluoroquinolones. They should be used with caution especially in people who are at higher risk of tendon injury caused by fluoroquinolone and quinolone antibiotics, such as older people, or people with kidney problems or who have had an organ transplantation or those who are having treatment with a systemic corticosteroid. Prescribing information for healthcare professionals and information for patients will be updated accordingly.
Addressing healthcare-associated C. difficile infection remains a key issue on which NHS organisations have been mandated to implement national guidance. PHE guidance on the management and treatment of C. difficile infection recommends a suitable approach. This guideline is currently being updated. NICE's medicines evidence commentary on comparative efficacy of antibiotics for C. difficile infection discusses a systematic review and meta-analysis considering the efficacy of antibiotics for adults with this infection.
The Department of Health and PHE report on C. difficile infection: how to deal with the problem from 2008 recommends that trusts should develop restrictive antibiotic guidelines that use narrow-spectrum agents alone or in combination as appropriate. The report suggests that these guidelines should avoid recommending clindamycin and second- and third-generation cephalosporins (especially in older people) and should recommend minimising the use of quinolones, carbapenems (for example, imipenem and meropenem) and prolonged courses of aminopenicillins (for example, ampicillin and amoxicillin). NICE guidance on antimicrobial stewardship recommends that antibiotics should be used only when indicated by the person's clinical condition, and their use should be reviewed after the results of microbiological testing or based on the sensitivities of causative bacteria where appropriate.
A NICE evidence summary on C. difficile infection: risk with broad-spectrum antibiotics reviews the evidence on this issue. It concludes that meta‑analyses in people with hospital‑associated and community‑associated C. difficile infection confirmed that the antibiotics most strongly associated with the infection were clindamycin, cephalosporins and quinolones. However, the interpretation of data on the risk of C. difficile with different antibiotics is extremely difficult. Such data should be interpreted with caution and should not be considered to definitively show which antibiotics or subgroups of antibiotic classes carry higher risks of C. difficile infection. Although the data have limitations that prevent firm conclusions, the evidence shows the importance of following antibiotic guidelines that recommend that all broad‑spectrum antibiotics are prescribed appropriately and with careful stewardship.
According to PHE guidance on managing common infections in primary care, cefalexin, other cephalosporins (cefixime, cefotaxime and ceftriaxone) and quinolones (for example, ciprofloxacin and ofloxacin) should be used only in limited situations. The ESPAUR report 2018 found that broad-spectrum antibiotic use continues to decrease in primary care. However, despite low levels of use and resistance, the proportion of bloodstream infections resistant to third-generation cephalosporins and ciprofloxacin has not changed significantly in the last 5 years.
Although identifying cephalosporins and quinolones as 'high risk' may have been an important control measure in reducing the risk of C. difficile infection, an unintended consequence of this may have been an increase in clinically inappropriate prescribing of co-amoxiclav and other broad-spectrum antibiotics, such as piperacillin-tazobactam, carbapenems and co-trimoxazole. According to PHE guidance on managing common infections in primary care, these antibiotics have a very limited set of recommended clinical indications.
The ESPAUR report 2018 reports that use of broad-spectrum antibiotics continues to decline. The mean proportion of co-amoxiclav, cephalosporins and quinolones as a proportion of all antibiotic items prescribed in primary care reduced from 10.7% to 8.9% between 2015 and 2017. Until 2015, hospitals were continuing to increase their use of the antibiotics of last resort (piperacillin/tazobactam, carbapenems and colistin). However, in 2017/18, 23%, 75% and 45% of 152 NHS acute trusts met their objectives to reduce total antibiotic, piperacillin/tazobactam and carbapenem consumption, respectively. The global shortage of piperacillin/tazobactam in 2017 has influenced the fall in consumption of this particular antibiotic but the overall, general downward trend is an encouraging step towards improving antibiotic stewardship in hospitals.
An audit and questionnaire survey to establish what proportion of sickness policies of UK childcare providers comply with PHE guidance, discussed in NICE's medicines evidence commentary on infective conjunctivitis: do childcare provider policies help drive inappropriate prescribing of antimicrobials?, found that only 13% of childcare provider policies reflected PHE advice and almost half required treatment with antibiotics before the child could be readmitted to nursery. In a questionnaire survey of primary care prescribers, about 40% said that childcare provider policy had been the main or only reason for prescribing topical antibiotics for infective conjunctivitis in children.
More information on antimicrobial stewardship and managing infections can be found in NICE's clinical knowledge summaries, antimicrobial prescribing guidelines, and various guidelines, pathways and quality standards on antibiotic use and infections. The Department of Health and Social Care webpage on antimicrobial resistance includes resources for healthcare professionals to help improve infection prevention and control practices and prescribing.
There are several NICE shared learning case studies relating to antimicrobial stewardship, showing how NICE guidance and standards have been put into practice by some NHS organisations: