Do Not Do Recommendation

Do Not Do Recommendation Details

Recommendation:

Do not use immunoglobulin G (IgG) anti-gliadin antibody (AGA) test in the diagnosis of coeliac disease.

Interventions:

immunoglobulin G (IgG) anti-gliadin antibody (AGA) test

Source guidance details

Guidance:

Coeliac disease (CG86)

Published date:

May 2009

Paragraph number:

1.1.13

Page number:

12

View all NICE do not do from this Guidance

• Do not use serological testing for coeliac disease in infants before gluten has been introduced to the diet.
• Do not use immunoglobulin A (IgA) anti-gliadin antibody (AGA) test in the diagnosis of coeliac disease.
• Do not use of self-tests and/or point-of-care tests for coeliac disease as a substitute for laboratory-based testing.
• Do not use human leukocyte antigen (HLA) DQ2/DQ8 testing in the initial diagnosis of coeliac disease. (However, its high negative predictive value may be of use to gastrointestinal specialists in specific clinical situations.)
• Based on limited clinical evidence, combination testing with IgA tTGA and IgA EMA does not appear to substantially to improve accuracy in the diagnostic process.
• [Do not use] deamidated gliadin tests and point-of-care tests or self tests [until supported by further evidence].