Do Not Do Recommendation

 

The following strategies should not be used routinely:

  • augmentation of an antidepressant with a benzodiazepine for more than 2 weeks as there is a risk of dependence
  • augmentation of an antidepressant with buspirone*, carbamazepine*, lamotrigine* or valproate* as there is insufficient evidence for their use
  • augmentation of an antidepressant with pindolol* or thyroid hormones* as there is inconsistent evidence of effectiveness[16].

Do Not Do Recommendation Details

Recommendation:

The following strategies should not be used routinely:

  • augmentation of an antidepressant with a benzodiazepine for more than 2 weeks as there is a risk of dependence
  • augmentation of an antidepressant with buspirone*, carbamazepine*, lamotrigine* or valproate* as there is insufficient evidence for their use
  • augmentation of an antidepressant with pindolol* or thyroid hormones* as there is inconsistent evidence of effectiveness[16].
Interventions:
Combining and augumenting medications

Source guidance details

Guidance:
Depression in adults: recognition and management (CG90)
Published date:
June 2016
Paragraph number:
1.8.1.9
Page number:
30

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