This guideline covers the diagnosis and management of venous thromboembolic diseases in adults (aged 18 and over), and the role of thrombophilia testing. It aims to clarify which diagnostic tests should be used, reduce variation in pharmacological therapies, and provide guidance on when thrombophilia testing is useful.
This guideline was previously called venous thromboembolic diseases: the management of venous thromboembolic diseases and the role of thrombophilia testing.
This updated guideline includes recommendations on:
Who is it for?
- Commissioners and providers of venous thromboembolism services
- Healthcare professionals in primary, secondary and tertiary care
- Adults (18 and over) with suspected or confirmed deep vein thrombosis or pulmonary embolism, and their families and carers
- First-degree relatives of people with inherited thrombophilia or other venous thromboembolic diseases
Is this guideline up to date?
We reviewed the evidence in November 2016 and we are updating the recommendations in the following 3 areas of the guideline:
- Diagnostic investigations for pulmonary embolism (PE)
- Pharmacological interventions – anticoagulation treatment for deep vein thrombosis (DVT) or PE*
- Investigations for cancer
* The proposed update to pharmacological interventions is limited to anticoagulant treatments and does not include pharmacological thrombolysis or analgesia.
Guideline development process
The recommendations in this guideline represent the view of NICE, arrived at after careful consideration of the evidence available. When exercising their judgement, professionals are expected to take this guideline fully into account, alongside the individual needs, preferences and values of their patients or service users. The application of the recommendations in this guideline is not mandatory and the guideline does not override the responsibility of healthcare professionals to make decisions appropriate to the circumstances of the individual patient, in consultation with the patient and/or their carer or guardian.
Local commissioners and/or providers have a responsibility to enable the guideline to be applied when individual health professionals and their patients or service users wish to use it. They should do so in the context of local and national priorities for funding and developing services, and in light of their duties to have due regard to the need to eliminate unlawful discrimination, to advance equality of opportunity and to reduce health inequalities. Nothing in this guideline should be interpreted in a way that would be inconsistent with compliance with those duties.